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ORGENTEC公司成立于1988年，公司总部位于德国的美因茨市。主要产品包括ABC试剂盒，各种标记二抗，Western试剂盒，蛋白分子量Marker，核抽提物等。ORGENTEC致力为免疫检测用户提供更多的产品与服务。
Anti-MCV?
The Anti-MCV? ELISA by ORGENTEC detects autoantibodies against mutated citrullinated vimentin (MCV) and is an efficient and reliable serological test for rheumatoid arthritis. Anti-MCV? detects the disease at a very early stage, even in patients who test negative for rheumatoid factor, and to some degree even before the appearance of specific clinical symptoms.
Autoantibodies against mutated citrullinated vimentin are highly specific and extremely sensitive markers for rheumatoid arthritis (specificity 97 %, sensitivity > 82 %). Anti-MCV? autoantibodies are an indicator of advanced injury to the joints and aggressive progression of the disease. In contrast to the detection of antibodies against synthetic cyclic citrullinated peptides, changes in the anti-MCV concentration correspond to changes of clinical parameters. As well as allowing for an unambiguous diagnosis, the Anti-MCV? ELISA thus also makes it possible to monitor therapeutic progress.
For point-of-care diagnosis, rheumachec? provides a rapid blood test that detects both anti-MCV autoantibodies and rheumatoid factor.
| Tests | 12 x 8 determinations | |
| Productnumber | ORG 548 | |
| Calculation | quantitative | |
| Range | 0-1000 U/ml | |
| Cut-off | 20 U/ml | |
| Sensitivity | 1 U/ml | |
| Calibration | arbitrary | |
| Substrate | TMB | |
| Antigens | MCV (mutated citrullinated vimentin) | |
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